Mannit Instrukcija ((FULL))

Diuretics: Serum osmolality should be kept at 295 to 320 mOsm/kg. Osmotic diuretics (eg, mannitol) may be given IV to lower ICP and maintain serum osmolality. These drugs do not cross the blood-brain barrier. They pull water from brain tissue across an osmotic gradient into plasma, eventually leading to equilibrium. Fluid and electrolyte balance should be monitored closely while osmotic diuretics are used. A 3% saline solution is another potential osmotic agent to control ICP.

mannit instrukcija

Brain herniation due to tumors is treated with mannitol (recommended dosage is 0.5 to 1.5 g/kg/dose IV with mannitol 20 to 25% concentration every 4 to 6 hours as required,) a corticosteroid (eg, dexamethasone 16 mg IV, followed by 4 mg orally or IV every 6 hours), and endotracheal intubation. Hyperventilation to a carbon dioxide partial pressure (PCO2) of 26 to 30 mm Hg can help decrease ICP temporarily in emergencies. Mass lesions should be surgically decompressed as soon as possible. 041b061a72